09:30 – 09:40 | Welcome Hubert Löwenheim |
09:40 – 09:50 | Welcome Boris Palmer (Lord mayor of Tübingen) |
09:50 | Session 01 - Drug Delivery and Advanced Genetic Diagnostics |
09:50 – 10:00 | Introduction |
10:00 – 10:30 | Eliot Shearer (Harvard University) |
“Diagnostic Evaluation for Children with Hearing Loss in the Ear of Gene Therapy” |
10:30 – 11:00 | Anil Lalwani (Columbia University) |
"Microneedle Mediated Safe and Precise Inner Ear Delivery" |
11:00 - 11:30 | Christoph Arnoldner (Vienna University) |
"Drug Delivery Studies in the Pig as Large Animal Model" |
11:30 - 12:00 | Round table |
12:00 | Lunch |
13:00 | Session 02 - Current Gene Therapy Trials |
13:00 – 13:10 | Introduction |
13:10 – 13:30 | Géraldine Honnet (Sensorion) |
"SENS-501 Gene Therapy in Young Children with Severe to Profound Hearing Loss Due to Otoferlin Mutations" |
13:30 – 13:50 | Carleton E. Corrales (Regeneron) |
“Safety and efficacy of DB-OTO gene therapy in children with profound deafness due to otoferlin variants: Data from the CHORD phase 1/2 open-label trial” |
13:50 – 14:10 | Aaron Tward (Akouos/Lilly) |
"Clinical Development of AK-OTOF Gene Therapy for OTOF-mediated Hearing Loss: Preliminary Results" |
14:10 – 14:30 | Yuxin Chen (Eye & ENT Hospital, Fudan University) |
" Gene Therapy vs Cochlear Implantation in Restoring Hearing Function and Speech Perception for Congenital Deafness Individuals" |
14:30 - 15:00 | Round table |
15:00 | Break |
15:30 | Session 03 - Stem Cell Therapies & Organoids |
15:30 - 15:40 | Introduction |
15:40 - 16:00 | Wouter H. van der Valk (Leiden University Medical Center) |
"From Inner Ear Organoids to Development and Back Again" |
16:00 - 16:20 | Pascal Senn (Geneva University) |
"From Regeneration of Auditory Neurons to Drug Screening" |
16:20 - 16:40 | Marcello Rivolta (Rinri Tx) |
“Recent Advances in the Development of a Pluripotent Stem-Cell Based Therapy for the Treatment of Hearing Loss” |
16:40 - 17:10 | Round table |
19:00 | Welcome reception |