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Symposium 13 September 2025 | Molecular Otology

08:30–09:30   Registration
09:30   Opening Hubert Löwenheim
09:30–09:40   Welcome Boris Palmer (Lord Mayor of Tübingen)
09:40–09:50   Welcome Hendrik Rosewich (Speaker, Centre for Rare Diseases, Tübingen)
09:50–10:00   Welcome and Introduction to the Symposium, Hubert Löwenheim
10:00   Session 01-  Advanced Genetic Diagnostics, Drug Delivery and Drug Therapy
Moderators: Ronald Pennings, Anke Tropitzsch
10:00–10:30   Eliot Shearer (Harvard University)
“Diagnostic Evaluation for Hearing Loss in the Era of Gene Therapy”
10:30–10:50   Anil Lalwani (Columbia University)
"Microneedle-Mediated Safe and Precise Inner Ear Delivery"
10:50–11:10   Christoph Arnoldner (Vienna University)
"Drug Delivery Studies in the Large Animal Model Pig"
11:10–11:30   Jonathan Kil (Sound Pharmaceuticals)
“Drug Development and Clinical Trials"
11:30–12:00   Round table
Moderators: Ronald Pennings, Anke Tropitzsch
Panelists: Eliot Shearer, Anil Lalwani, Christoph Arnoldner, Jonathan Kil
12:00   Lunch
13:00   Session 02 - Current Gene Therapy Trials
Moderators: Hinrich Staeker, Hubert Löwenheim
13:00–13:20   Géraldine Honnet (Sensorion)
"SENS-501 Gene Therapy in Young Children with Severe to Profound Hearing Loss Due to Otoferlin Mutations"
13:20–13:40   Carleton E. Corrales (Regeneron)
“Safety and Efficacy of DB-OTO Gene Therapy in Children with Profound Deafness due to Otoferlin Variants: Data from the CHORD Phase 1/2 Open-label Trial”
13:40–14:00   Aaron Tward (Akouos/Lilly)
"Clinical Development of AK-OTOF Gene Therapy for OTOF-mediated Hearing Loss: Preliminary Results"
14:00–14:20   Yuxin Chen (Eye & ENT Hospital, Fudan University)
"Gene Therapy vs Cochlear Implantation in Restoring Hearing Function and Speech Perception for Congenital Deafness Individuals"
14:20–15:00   Round table
Moderators: Hinrich Staecker, Hubert Löwenheim
Panelists: Géraldine Honnet, Carleton E. Corrales, Aaron Tward, Yuxin Chen
15:00   Break
15:30   Session 03 - Stem Cell Therapies & Organoids
Moderators: Athanasia Warnecke, Thore Schade-Mann
15:30–15:50   Heiko Locher (Leiden University Medical Center)
"Mapping and Modeling the Human Inner Ear: RNA Atlases, Organoids, and Clinical Applications"
15:50–16:10   Pascal Senn (University Hospital of Geneva)
"From Regeneration of Auditory Neurons to Drug Screening"
16:10–16:30   Marcelo Rivolta (Rinri Therapeutics)
“Recent Advances in the Development of a Pluripotent Stem-Cell Based Therapy for the Treatment of Hearing Loss”
16:30–17:00   Round Table
Moderators: Athanasia Warnecke, Thore Schade-Mann
Panelists: Heiko Locher, Pasacal Senn, Marcelo Rivolta
17:00–19:00   Welcome reception
at the Rooftop of the congress venue

Please click here for the detailed programme.