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Symposium 13 September 2025 | Molecular Otology

09:30 – 09:40 Welcome Hubert Löwenheim
09:40 – 09:50 Welcome Boris Palmer (Lord mayor of Tübingen)
09:50 Session 01 -  Drug Delivery and Advanced Genetic Diagnostics
09:50 – 10:00 Introduction
10:00 – 10:30 Eliot Shearer (Harvard University)
“Diagnostic Evaluation for Children with Hearing Loss in the Ear of Gene Therapy”
10:30 – 11:00 Anil Lalwani (Columbia University)
"Microneedle Mediated Safe and Precise Inner Ear Delivery"
11:00 - 11:30 Christoph Arnoldner (Vienna University)
"Drug Delivery Studies in the Pig as Large Animal Model"
11:30 - 12:00 Round table
12:00 Lunch
13:00 Session 02 - Current Gene Therapy Trials
13:00 – 13:10 Introduction
13:10 – 13:30 Géraldine Honnet (Sensorion)
"SENS-501 Gene Therapy in Young Children with Severe to Profound Hearing Loss Due to Otoferlin Mutations"
13:30 – 13:50 Carleton E. Corrales (Regeneron)
“Safety and efficacy of DB-OTO gene therapy in children with profound deafness due to otoferlin variants: Data from the CHORD phase 1/2 open-label trial”
13:50 – 14:10 Aaron Tward (Akouos/Lilly)
"Clinical Development of AK-OTOF Gene Therapy for OTOF-mediated Hearing Loss: Preliminary Results"
14:10 – 14:30 Yuxin Chen (Eye & ENT Hospital, Fudan University)
" Gene Therapy vs Cochlear Implantation in Restoring Hearing Function and Speech Perception for Congenital Deafness Individuals"
14:30  - 15:00 Round table
15:00 Break
15:30 Session 03 - Stem Cell Therapies & Organoids
15:30 - 15:40 Introduction
15:40 - 16:00 Wouter H. van der Valk (Leiden University Medical Center)
"From Inner Ear Organoids to Development and Back Again"
16:00 - 16:20 Pascal Senn (Geneva University)
"From Regeneration of Auditory Neurons to Drug Screening"
16:20 - 16:40 Marcello Rivolta (Rinri Tx)
“Recent Advances in the Development of a Pluripotent Stem-Cell Based Therapy for the Treatment of Hearing Loss”
16:40 - 17:10 Round table
19:00 Welcome reception