08:30 – 09:30 Registration
09:30 Opening, Anthony Gummer & Hubert Löwenheim
09:30 – 09:40 Welcome, Boris Palmer (Lord Mayor of Tübingen)
09:40 – 09:50 Welcome, Hendrik Rosewich (Speaker, Center for Rare Disease, Tübingen)
09:50 – 10:00 Welcome and Introduction to the Symposium, Hubert Löwenheim
10:00 Session 01: Advanced Genetic Diagnostics, Drug Delivery and Drug Therapy
Moderators: Ronald Pennings, Anke Tropitzsch
10:00 – 10:30 Eliot Shearer (Harvard University)
"Diagnostic Evaluation for Hearing Loss in the Era of Gene Therapy”
10:30 – 10:50 Anil K. Lalwani (Columbia University)
"Microneedle-Mediated Safe and Precise Inner Ear Delivery"
10:50 - 11:10 Christoph Arnoldner (Vienna University)
"Drug Delivery Studies in the Large Animal Model Pig"
11:10 – 11:30 Jonathan Kil (Sound Pharmaceuticals)
“Drug Development and Clinical Trials”
11:30 - 12:00 Round table
Moderators: Pennings, Tropitzsch
Panelists: Shearer, Lalwani, Arnoldner, Kil
12:00 – 13:00 Lunch
13:00 Session 02: Current Gene Therapy Trials
Moderators: Hinrich Staeker, Hubert Löwenheim
13:00 – 13:20 Géraldine Honnet (Sensorion)
"SENS-501 Gene Therapy in Young Children with Severe to Profound Hearing Loss Due to Otoferlin Mutations"
13:20 – 13:40 Carleton E. Corrales (Regeneron)
“Safety and Efficacy of DB-OTO Gene Therapy in Children with Profound Deafness due to Otoferlin Variants: Data from the CHORD Phase 1/2 Open-label Trial”
13:40 – 14:00 Aaron Tward (Akouos/Lilly)
"Clinical Development of AK-OTOF Gene Therapy for OTOF-mediated Hearing Loss: Preliminary Results"
14:00 – 14:20 Yuxin Chen (Eye & ENT Hospital, Fudan University)
"Gene Therapy vs Cochlear Implantation in Restoring Hearing Function and Speech Perception for Congenital Deafness Individuals"
14:20 - 15:00 Round table
Moderators: Staecker, Löwenheim
Panelists: Honnet, Corrales, Tward, Chen
15:00 – 15:30 Break
15:30 Session 03: Stem Cell Therapies & Organoids
Moderators: Athanasia Warnecke, Thore Schade-Mann
15:30 - 15:50 Heiko Locher (Leiden University Medical Center)
"Mapping and Modeling the Human Inner Ear: RNA Atlases, Organoids, and Clinical Applications"
15:50 - 16:10 Pascal Senn (Geneva University)
"From Regenerating Auditory Neurons To Drug Screening"
16:10 - 16:30 Marcelo Rivolta (Rinri Tx)
“Recent Advances in the Development of a Pluripotent Stem-Cell Based Therapy for the Treatment of Hearing Loss”
16:30 - 17:00 Round table
Moderators: Warnecke, Schade-Mann
Panelists: Locher, Senn, Rivolta
17:00 - 19:00 Welcome reception
at the Rooftop of the congress venue
Please click here for the detailed programme.